American Society for Peripheral Nerve

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Lymphocyte Subset in Blood is the Helpful Tool for Diagnosis of Autoimmune Peripheral Neuropathy
Hitoshi Mori, MD
Neurology, Kurashiki Central Hospital, Kurashiki,Okayama, Japan

Introduction: Cervical spinal canal stenosis, disk hernia, myelopahty, amyotrophic lateral sclerosis (ALS) are often misdiagnosed in peripheral neuropathy patients, especially in multifocal motor neuropathy.

Methods: We show the six cases which were misdiagnosed by other facilities as ALS, myelopathy, disc hernia through conventional study. By using combination of careful physical neurological examinations and extended nerve conduction study, these patients were diagnosed as peripheral neuropathy with conduction block such as multifocal motor neuropathy. We looked for convenient and helpful tools for differential diagnosis, and found the lymphocyte subsets in blood.

Results: All of the six cases show abnormal lymphocyte subsets in the blood, such as CD4, CD8, CD4/CD8, CD3, CD19. Because these abnormal findings are not shown in ALS, cervical spinal canal stenosis, disk hernia, myelopathy, lymphocyte subsets in blood show underlying abnormality of autoimmune peripheral neuropathy.

Conclusions: Lymphocyte subset in blood is the helpful tool for diagnosis of autoimmune neuropathy, especially multifocal motor neuropathy.

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