Lung Function of A New Nerve Repair Modal in Rat: Using Phrenic Nerve Ad Intercostal Nerve as Donor by Side-to-Side Neurorrhaphy
Jing Rui, M.D., Ph.D
Department of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, China
Objective: To verify the safety of a new surgical model by assessing the lung function of phrenic nerve and intercostal nerve via side-to-side with nerve autograft to the anastomosis site of the musculocutaneous nerve in rat.
Methods: Fifty four SD rats were randomly divided into three groups. Group A was the negative control group, in which the musculocutaneous nerve was transected and directly anastomosed. The other two groups were the phrenic nerve (group B) and intercostal nerve (group C): after the musculocutaneous nerve was tansected and directly anastomosed the side-to-side anastomosis was conducted. We used sural nerve to connect the musculocutaneous nerve anastomosis site and the donor nerve as phrenic nerve and intercostal nerve, representatively. Lung function text was conducted at one month, two months and three months postoperative and each 6 rats in each group were sacrificed at every time point.
Results: No significant difference was detected from any parameter about lung function test among group A, group B and group C at one month, two months and three months postoperative.
Conclusion: There was no obvious damage to the lung function by using side-to-side nerve anastomosis. This new procedure has more secure and advantage, which gets a big potential to apply in clinic.
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